Detecting Heterogeneous Treatment Effects to Guide Personalized Blood Pressure Treatment

Capturing Behavioral Biomarkers to Guide Personalized Treatment

Embedded health assessment using in-home sensors is being tested in TigerPlace, a 54-unit senior housing site that supports aging in place. We present case studies of TigerPlace residents which illustrate how behavioral biomarkers from in-home sensors can be used to personalize treatment.

Blood pressure response to treatment.

Target Blood Pressure for Treatment

The guidelines on the management of hypertension released by European and US Task Forces in 2013 and 2014 recommend target blood pressure (BP) levels below 140/90 mm Hg in most hypertensive patients, with higher values (<150/90 mm Hg) in the elderly. However, recent randomized trials as well as new metaanalyses of the available data have obtained results that are not consistent with these recom...

Personalized antipsychotic treatment: the adverse effects perspectives.

Antipsychotics are the lodestar in the treatment of schizophrenia despite the variability of the therapeutic response and drug-induced adverse effects (especially extrapyramidal symptoms, gain weight, and metabolic disturbances). More and more data are supporting the notion that genetic factors - as well as often overlooked personal and environmental factors - that define the inter-individual d...

Prevention and Treatment of Hypertension Study (PATHS): effects of an alcohol treatment program on blood pressure.

OBJECTIVE To determine whether blood pressure is reduced for at least 6 months with an intervention to lower alcohol intake in moderate to heavy drinkers with above optimal to slightly elevated diastolic blood pressure, and whether reduction of alcohol intake can be maintained for 2 years. DESIGN A randomized controlled trial. METHODS Six hundred forty-one outpatient veterans with an averag...